Cardiovascular Anatomy, Pathology and Histology
Normal human anatomy and the structure of arteries and veins will be examined. Pathogenesis of common vascular diseases will be observed using gross anatomic specimens. Histological techniques to study the vascular wall, including light microscopy, electro microscopy, biochemistry, and immunohistochemistry will be presented. Changes to the vessel wall due to viomechanical forces and disease processes will be demonstrated.

Cardiovascular Molecular and Cell Biology
Molecular biologic techniques including cell culture, northern and western blotting, RT-PCR, and gene expression profiling using cDNA microarrays will be covered. The effect of biomechanical forces on endothelial and smooth muscle cells will be observed.

Benchtop Experimental Methods
Fundamental fluid measurement techniques, applicable in vivo and in vitro, will be demonstrated in anatomic replicas. The design of an anatomically and physiologically representative flow system including pump, flow models, fluids, and downstream capacitive and resistive elements will be presented.

Intravascular Diagnostics and Interventions
Intravascular ultrasound, pressure, flow and fractional flow reserve measurements will be demonstrated. Clinical perspectives on interventional strategies will be presented.

Noninvasive Imaging
Ultrasound, magnetic resonance imaging (MRI), and computed tomography (CT), commonly used for noninvasive vascular imaging will be considered. Case studies will be presented illustrating how these techniques can be used to acquire anatomic and physiologic data for diagnoses, patient follow-up, device design, and device evaluation.

Computer Modeling Methods and Applications
Fundamental modeling techniques for quantifying blood flow and tissue mechanical behavior will be presented. Geometric modeling, mesh generation, finite element analysis and scientific visualization techniques will be presented with an emphasis on virtual prototyping of medical devices.

For more information about this course please contact:
Lindsey Akin - ProEd Program Coordinator
1.650.725.9200
proed_reg@scpdinfo.stanford.edu